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Cleaning Science

Small Molecule API
Cleaning Optimization

Project

Outcome
1

Cleaning failures limited to 5% of systems (inherent design issue).

2

Cleaning turnaround reduced to 32 shifts (multi-stranded).

3

Operational savings of ~ €3.75 million per cleaning operation.

4

Batch capacity increased by 27 per annum.

Project

Goals

Project

at a Glance

This confidential client saved ~€3.75M per cleaning operation while limiting cleaning failures to less than 5%.

About

Hyde Engineering + Consulting

Hyde Engineering + Consulting has been a global leader in process system design, commissioning, and FDA compliance for regulated industries since 1993.

Our Results

40 - 60%

Reduction in Chemical Consumption

45 - 70%

Increase in CIP System Availability

40 - 70%

Reduction in Water Consumption

1.5 - 2.5x

Increase in Manufacturing Throughput

Project

Components

System Flowrate Analysis

Solvent Selection Rationalization

Cleaning Cycle Analysis